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Dahl's sign (also Thinker's sign or Target sign)〔Pavithran K. Thinker's sign. Indian J Dermatol Venereol Leprol 1992;58:266-7. (Full text )〕 is a clinical sign in which areas of hyperpigmentation are seen on the skin of the lower thighs and elbows. It occurs in patients with longstanding severe chronic obstructive pulmonary disease. The sign occurs because patients with COPD tend to sit forwards with their arms resting on their thighs, leading to chronic erythema of the skin at the points of contact. Over time, haemosiderin released from red blood cells trapped in the skin is released causing a brown discolouration of the skin. Air trapping in the lungs of COPD patients causes the diaphragm to be pushed down and flattened, which reduces the effect of contraction of the diaphragm during inspiration. Sitting forwards pushes the abdominal contents upwards, increasing the curvature of the diaphragm and improving its effectiveness.〔Jeff Wiese, Stephen Bent, Sanjay Saint. ''Clinical Clerkships'', page 252. Lippincott, Williams & Wilkins, 2005. ISBN 978-0-7817-3754-8.〕 Bilateral cubital tunnel syndrome may also be found in patients with Dahl's sign.〔Dale Berg, Katherine Worzala. ''Atlas of adult physical diagnosis'', page 365. Lippincott, Williams & Wilkins, 2006. ISBN 978-0-7817-4190-3.〕 Dahl's sign was described by K.V. Dahl in 1970.〔 == References == 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Dahl's sign」の詳細全文を読む スポンサード リンク
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